5/31/2023 0 Comments Unlock trial keyshapeMeanwhile, bacteria can deliver the cytokines, antibody, and other anticancer theranostic nanoparticles to tumor microenvironments by regulating the expression of the bacterial genes or chemical and physical loading. More importantly, the design of engineering bacteria with detoxification and specificity is essential for the efficacy of bacteria-based cancer therapeutics. In particular, bacteria have demonstrated their anticancer effect through the toxins, and other active components from the cell membrane, cell wall, and dormant spores. Compared to traditional cancer treatments such as surgery, chemotherapy, radiotherapy, and phototherapy, bacteria-based cancer immunotherapy exhibits the versatile capabilities for suppressing cancer thanks to its preferentially accumulating and proliferating within tumors. Owing to its unique mechanism of abundant pathogen-associated molecular patterns in antitumor immune responses, bacteria-based cancer immunotherapy has recently attracted wide attention. A preliminary in vitro hyperthermia study, working onĬlinical conditions, reveals that cancer cell proliferation is strongly affectedīy the hyperthermia treatment, making these bacteria promising candidates These bacteria can be internalized by human lung carcinoma cells A549,Īnd cytotoxicity studies reveal that they do not affect the viability or growth Magnetotactic bacteria is perfect to enhance the hyperthermia efficiency.įurthermore, fluorescence and electron microscopy images show that The experimental resultsĭemonstrate that the biological structure of the magnetosome chain of The hyperthermia experiments is also investigated. The effect of the alignment of the bacteria in the direction of the field during Methods at different magnetic field amplitudes and frequencies. Their heating efficiency or specificĪbsorption rate is determined using both calorimetric and AC magnetometry Hyperthermia agents for cancer treatment. Strain Magnetospirillum gryphiswaldense present high potential as magnetic Here it is shown that magnetotactic bacteria of the Magnetotactic bacteria are aquatic microorganisms that internallyīiomineralize chains of magnetic nanoparticles (called magnetosomes) and
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